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Sensorineural hearing loss in insulin‐like growth factor I‐null mice: a new model of human deafness
Author(s) -
Cediel R.,
Riquelme R.,
Contreras J.,
Díaz A.,
VarelaNieto I.
Publication year - 2006
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2005.04584.x
Subject(s) - hearing loss , sensorineural hearing loss , inner ear , auditory brainstem response , auditory system , cochlea , insulin like growth factor , audiology , brainstem , neuroscience , growth factor , biology , psychology , endocrinology , medicine , receptor
It has been reported that mutations in the gene encoding human insulin‐like growth factor‐I (IGF‐I) cause syndromic hearing loss. To study the precise role of IGF‐I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF‐I deficiency. We show here that homozygous Igf‐1 – / – mice present an all‐frequency involved bilateral sensorineural hearing loss. Igf‐1 –/– mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf‐1 –/– mice. These results support the use of the Igf‐1 –/– mouse as a new model for the study of human syndromic deafness.