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A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats
Author(s) -
Mendoza Jorge,
AngelesCastellanos Manuel,
Escobar Carolina
Publication year - 2005
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2005.04461.x
Subject(s) - zeitgeber , suprachiasmatic nucleus , entrainment (biomusicology) , circadian rhythm , medicine , meal , endocrinology , nucleus , photoperiodism , circadian clock , biology , chemistry , rhythm , neuroscience
Food is considered a potent Zeitgeber for peripheral oscillators but not for the suprachiasmatic nucleus (SCN), which is entrained principally by the light–dark cycle. However, when food attains relevant properties in quantity and quality, it can be a potent Zeitgeber even for the SCN. Here we evaluated the entrainment influence of a daily palatable meal, without regular food deprivation, on the circadian rhythm of locomotor activity and the c‐Fos and PER‐1 protein expression in the SCN. Rats fed ad libitum , in constant darkness, received a palatable meal for 6 weeks starting in the middle of the subjective day. Locomotor activity showed entrainment when the offset of activity coincided with the palatable meal‐time. In the SCN, the peak expression of c‐Fos was observed at palatable meal‐time and PER‐1 showed a peak during the onset of subjective night, as predicted according to the behavioural entrained pattern. In addition, c‐Fos and PER‐1 expression in the paraventricular thalamic nucleus (PVT) showed increased expression at palatable meal‐time, while the intergeniculate leaflet did not, suggesting that the PVT may be involved as an input pathway of palatable food‐entrainment to the SCN. These results demonstrate that daily access to a palatable meal can entrain the SCN; several stimuli can be implicated in this process, including motivation and arousal.