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Dopamine D1‐like receptor modulates layer‐ and frequency‐specific short‐term synaptic plasticity in rat prefrontal cortical neurons
Author(s) -
Young Clint E.,
Yang Charles R.
Publication year - 2005
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2005.04161.x
Subject(s) - tetanic stimulation , long term potentiation , dopamine , neuroscience , excitatory postsynaptic potential , stimulation , glutamate receptor , chemistry , synaptic plasticity , glutamatergic , post tetanic potentiation , postsynaptic potential , biophysics , receptor , medicine , biology , inhibitory postsynaptic potential , biochemistry
The mesocortical dopamine (DA) input to the prefrontal cortex (PFC) is crucial for processing short‐term working memory (STWM) to guide forthcoming behavior. Short‐term plasticity‐like post‐tetanic potentiation (PTP, < 3 min) and short‐term potentiation (STP, < 10 min) may underlie STWM. Using whole‐cell voltage‐clamp recordings, mixed glutamatergic excitatory postsynaptic currents (EPSCs) evoked by layer III or layer V stimulation (0.5 or 0.067 Hz) were recorded from layer V pyramidal neurons. With 0.5 Hz basal stimulation of layer III, brief tetani (2 × 50 Hz) induced a homosynaptic PTP (decayed: ∼1 min). The D1‐like antagonist SCH23390 (1 µ m ) increased the PTP amplitude and decay time without inducing changes to the tetanic response. The tetani may evoke endogenous DA release, which activates a presynaptic D1‐like receptor to inhibit glutamate release to modulate PTP. With a slower (0.067 Hz) basal stimulation, the same tetani induced STP (lasting ∼4 min, but only at 2× intensity only) that was insignificantly suppressed by SCH23390. With stimulation of layer‐V→V inputs at 0.5 Hz, layer V tetani yielded inconsisitent responses. However, at 0.067 Hz, tetani at double the intensity resulted in an STP (lasting ∼6 min), but a long‐term depression after SCH23390 application. Endogenous DA released by tetanic stimulation can interact with a D1‐like receptor to induce STP in layer V→V synapses that receive slower (0.067 Hz) frequency inputs, but suppresses PTP at layer III→V synapses that receive higher (0.5 Hz) frequency inputs. This D1‐like modulation of layer‐ and frequency‐specific synaptic responses in the PFC may contribute to STWM processing.