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Synaptic plasticity in the absence of backpropagating spikes of layer II inputs to layer V pyramidal cells in rat visual cortex
Author(s) -
Stiefel Klaus M.,
Tennigkeit Frank,
Singer Wolf
Publication year - 2005
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2005.04094.x
Subject(s) - excitatory postsynaptic potential , neuroscience , long term potentiation , postsynaptic potential , metabotropic glutamate receptor , neurotransmission , synaptic plasticity , pyramidal cell , chemistry , glutamate receptor , biology , inhibitory postsynaptic potential , receptor , hippocampus , biochemistry
Use‐dependent changes of synaptic transmission are thought to depend on the evaluation of temporal correlations between pre‐ and postsynaptic excitatory activity. Previous studies have demonstrated long‐term potentiation (LTP) in layer V pyramidal cells after coincident pairing of presynaptic excitatory input with postsynaptic depolarizations, evoking backpropagating action potentials (BAPs). Here we paired excitatory layer II input with somatic hyperpolarization, which blocked BAPs in layer V pyramidal cells of rat visual cortex and induced reliable long‐term depression (LTD). Upon cholinergic receptor activation, this BAP‐independent protocol also induced LTP, which was not dependent on N ‐methyl‐ d ‐aspartate receptor activation, but blocked by metabotropic glutamate receptor (mGluR) antagonists.