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Organization of Glutamate Receptors at the Synapse
Author(s) -
Ottersen Ole P.,
Landsend Alf S.
Publication year - 1997
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1997.tb01640.x
Subject(s) - glutamate receptor , glutamatergic , neuroscience , metabotropic glutamate receptor 6 , receptor , metabotropic glutamate receptor 2 , neurotransmission , synapse , silent synapse , biology , metabotropic glutamate receptor 7 , microbiology and biotechnology , metabotropic glutamate receptor , chemistry , biochemistry
Glutamate receptors can be divided in several groups with distinct functional properties. An additional level of complexity has emerged from recent high resolution immunogold analyses which have provided evidence for a differential targeting of glutamate receptors to specific subsynaptic membrane domains. Notably, different types of glutamate receptor may differ in their distance to the release site and in their spatial relation to glutamate transporters. These data imply that the subsynaptic expression of a given glutamate receptor may bias its response to a released quantum of transmitter and suggest that receptor targeting may be implicated in the modulation of glutamatergic neurotransmission.