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Ontogenetic Development of 5‐HT 1D Receptors in Human Brain: An Autoradiographic Study
Author(s) -
Olmo Elena,
Arco Carmen,
Díaz Alvaro,
Pascual Julio,
Mengod Guadalupe,
Palacios José M.,
Pazos Angel
Publication year - 1996
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1996.tb01166.x
Subject(s) - globus pallidus , receptor , 5 ht receptor , substantia nigra , basal ganglia , human brain , serotonin , biology , neuroscience , 5 ht4 receptor , period (music) , endocrinology , medicine , central nervous system , biochemistry , dopamine , physics , dopaminergic , acoustics
The pattern of pre‐ and postnatal appearance of 5‐HT 1D receptors throughout the different areas of the human brain was studied by quantitative in vitro autoradiography, using [ 125 I]GTI (serotonin O ‐carboxymethyl‐glycyl‐[ 125 I]tyrosinamide) as a ligand. The anatomical distribution of 5‐HT 1D receptors in neonatal, infant and children's brain was in good agreement with that observed in the adult, the basal ganglia and substantia nigra being the most intensely labelled areas. The development of these receptors throughout the human brain was mainly postnatal: low densities of [ 125 I]GTI binding sites were observed at the fetal/neonatal stage in most regions analyzed, in contrast with the high levels of labelling found in infant and children's brains. Indeed, in a number of regions, including the globus pallidus, substantia nigra and visual cortex, a peak of overexpression of 5‐HT 1D receptors was observed in the first decade of life. Such overexpression could support a regulatory role for 5‐HT 1D receptors in advanced periods of the CNS developmental process. Our results also indicate that the administration of drugs acting on 5‐HT 1D receptors during the early postnatal period of life could result in modifications of their properties, as these receptors are already functional in this period.