Premium
Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS
Author(s) -
Armanini M. P.,
McMahon S. B.,
Sutherland J.,
Shelton D. L.,
Phillips H. S.
Publication year - 1995
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1995.tb01132.x
Subject(s) - tropomyosin receptor kinase b , gene isoform , neurotrophin , neuroscience , biology , spinal cord , tropomyosin receptor kinase a , microbiology and biotechnology , nervous system , neurotrophic factors , receptor , gene , genetics
Localization of mRNA encoding trkB indicates that two truncated isoforms of trkB, T1trkB and T2trkB, are differentially distributed in the rodent nervous system, and that each of these transcripts is co‐expressed with catalytic trkB (TK+trkB) in adult motor neurons. In contrast to the prominent expression of T1trkB by non‐neuronal cells, T2trkB expression appeared to be restricted to neurons and demonstrated significant overlap with the pattern of TK+trkB distribution. In developing spinal cord ventral horn, an age‐related increase in hybridization was observed for truncated isoforms. These findings suggest that truncated trkB may modulate neuronal responses to neurotrophins which act via trkB.