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Human Recombinant Nerve Growth Factor Replaces Deficient Neurotrophic Support in the Diabetic Rat
Author(s) -
Fernyhough Paul,
Diemel Lara T.,
Hardy Jim,
Brewster Wendy J.,
Mohiuddin Liza,
Tomlinson David R.
Publication year - 1995
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1995.tb01098.x
Subject(s) - nerve growth factor , neurotrophic factors , neurotrophin , endocrinology , medicine , calcitonin gene related peptide , sciatic nerve , diabetic neuropathy , brain derived neurotrophic factor , pathogenesis , diabetes mellitus , neuropeptide , receptor
Manipulation of neurotrophic support is a developing strategy for new therapy aimed at neurodegenerative diseases. This study demonstrates reduced content and retrograde transport of endogenous nerve growth factor (NGF) in sciatic nerve of diabetic rats. There were also reductions in the diabetic rats in NGF protein and mRNA in skin and muscle of the hindlimb. These deficits correlated with reductions in substance P and calcitonin gene‐related peptide–both products of NGF‐influenced genes in primary afferents. These manifestations of deficient neurotrophic support were corrected by intensive insulin treatment and surmounted by administration of exogenous human recombinant NGF in a dose‐related manner. Impaired neurotrophic support may, therefore, participate in the pathogenesis of diabetic and other peripheral neuropathies.