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NMDA Receptor‐dependent Long‐term Potentiation in the Hippocampal Afferent Fibre System to the Prefrontal Cortex in the Rat
Author(s) -
Jay Thérèse M.,
Burette François,
Laroche Serge
Publication year - 1995
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1995.tb01060.x
Subject(s) - long term potentiation , neuroscience , nmda receptor , prefrontal cortex , hippocampal formation , 2 amino 5 phosphonovalerate , infralimbic cortex , hippocampus , stimulation , chemistry , long term depression , ltp induction , glutamate receptor , ampa receptor , biology , receptor , biochemistry , cognition , excitatory amino acid antagonists
This study investigated the role of the N ‐methyl‐ d ‐aspartate (NMDA) subtype of glutamate receptor in the induction of long‐term potentiation (LTP) in the hippocampal‐prefrontal cortex pathway in vivo. Field potentials evoked by electrical stimulation of the CA1/subicular region were recorded in the prelimbic area of the prefrontal cortex under continuous perfusion of artificial cerebrospinal fluid in anaesthetized rats. High‐frequency stimulation of the CA1/subicular region induced LTP of the evoked response in the prelimbic area of the prefrontal cortex. LTP was completely blocked when the selective NMDA receptor antagonist d ‐(‐)2‐amino‐5‐ phosphonopentanoic acid ( d ‐AP5; 200 μM), was perfused during the tetanus. Perfusion of D‐AP5 did not affect normal transmission or pre‐established LTP. These results demonstrate that induction of LTP in the hippocampal‐prefrontal cortex pathway is an NMDA receptor‐dependent process.