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Long‐term Depression in the Hippocampal CA1 Region is Associated with Equal Changes in AMPA and NMDA Receptor‐mediated Synaptic Potentials
Author(s) -
Xiao M.Y.,
Wigström H.,
Gustafsson B.
Publication year - 1994
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1994.tb00600.x
Subject(s) - ampa receptor , long term depression , excitatory postsynaptic potential , nmda receptor , neuroscience , postsynaptic potential , chemistry , hippocampal formation , glutamate receptor , biology , receptor , inhibitory postsynaptic potential , biochemistry
In the CA1 hippocampal region low‐frequency (1‐2 Hz) afferent activation leads to a long‐term depression of excitatory synaptic potentials that is induced by calcium influx through postsynaptic N ‐methyl‐ d ‐aspartate receptor channels. In the present experiments using 2‐ to 3‐week‐old rats, long‐term depressions of field excitatory postsynaptic potentials mediated by amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) and by N ‐methyl‐ d ‐aspartate receptor channels were examined in parallel, using a perfusion solution containing low concentrations of an AMPA receptor antagonist and of magnesium (0.1 mM). These experiments revealed that long‐term depression was associated with equal relative changes in the two components of the field potential, compatible with a presynaptic location of the expression mechanism for the long‐term depression.