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Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in the Mouse
Author(s) -
Raivich Gennadij,
MorenoFlores M. Teresa,
Möller J. Carsten,
Kreutzberg Georg W.
Publication year - 1994
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1994.tb00552.x
Subject(s) - microglia , macrophage colony stimulating factor , macrophage , colony stimulating factor , in vitro , endogeny , neuroscience , growth factor , microbiology and biotechnology , biology , immunology , inflammation , endocrinology , stem cell , receptor , genetics , haematopoiesis
Activation and proliferation of microglia are common cellular hallmarks in many different pathological processes of the central nervous system. Although a number of colony‐stimulating factors enhance microglial proliferation in vitro , little is known about the endogenous mitogens. In the present study we show a strong and selective inhibition of microglial proliferation in the facial nucleus of osteopetrotic (op/op) mice, with a genetic deficiency in biologically active macrophage colony‐stimulating factor (MCSF). Posttraumatic activation of adjacent axotomized neurons and reactive astrocytes was not affected, emphasizing the specificity of MCSF as a microglial growth factor.