Premium
A Unique Achiasmatic Anomaly Detected in Non‐albinos with Misrouted Retinal‐fugal Projections
Author(s) -
Apkarian Patricia,
Bour Lo,
Barth Peter G.
Publication year - 1994
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1994.tb00293.x
Subject(s) - retinal , optic chiasm , biology , neuroscience , visual system , retina , anatomy , optic nerve , biochemistry
In mammals with binocular vision, projections of retinal sons to primary retino‐recipient nuclei establish a strict visuotopic and eye‐segregated arrangement. Normal primate visual pathway organization is characterized by orderly hemiretina separation in which nasal‐retinal axons cross at the optic chiasm and project to primary contralateral subcortical and cortical structures while temporal‐retinal fibres project ipsilaterally to corresponding visual structures. We report here, in two unrelated children, an unusual visual pathway malformation in which nasal‐retinal cortical projections, unable to decussate due to the inborn absence of an optic chiasm, erroneously route ipsilaterally to visual projection targets. We have termed this newly documented achiasmatic condition the non‐decussating retinal‐fugal fibre syndrome ( Apkarian er al., Invest. Ophthalmol. Vis. Sci., 34, Suppl. , 711, 1993).