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The Role of Serotonin Receptor Subtypes in the Behavioural Effects of Neuroleptic Drugs. A Paw Test Study in Rats
Author(s) -
Ellenbroek Bart A.,
Prinssen Eric P. M.,
Cools Alexander R.
Publication year - 1994
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1994.tb00242.x
Subject(s) - ritanserin , clozapine , haloperidol , pharmacology , 5 ht2a receptor , agonist , sertindole , ketanserin , psychology , antipsychotic , fluphenazine , receptor antagonist , 5 ht receptor , serotonin , antagonist , medicine , receptor , schizophrenia (object oriented programming) , dopamine , neuroscience , psychiatry
The present study was designed to evaluate the roles of serotonin 5‐HT 1A and 5‐HT 2 receptors in the effects of neuroleptic drugs in the paw test. This behavioural test has been shown to model both the antipsychotic efficacy as well as the extrapyramidal side‐effect liability of neuroleptic drugs. Whereas the 5‐HT 1A receptor agonist 8‐hydroxy‐2‐(di‐ n ‐propylamino)tetralin (8‐OHDPAT) reduced the effects of the classical neuroleptic haloperidol, it increased the effects of the atypical neuroleptic clozapine. The 5‐HT 2 receptor antagonist ketanserin as well as the 5‐HT 1C /5‐HT 2 receptor antagonist ritanserin, on the other hand reduced the effects of haloperidol, whereas the 5‐HT 1C /5‐HT 2 receptor agonist 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOl) reduced the effects of clozapine. The most important finding, however, was that the behavioural effects of different (putative) neuroleptics (fluphenazine, SCH‐39166, remoxipride, prothipendyl, thioridazine and risperidone) were differentially influenced by both 8‐OHDPAT and DOl, suggesting that there are important differences between the neuronal mechanisms underlying the behavioural effects of these neuroleptic drugs, even within the subclasses of classical and atypical neuroleptics.