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Glutamate‐like Immunoreactivity in the Pigeon Optic Tectum and Effects of Retinal Ablation
Author(s) -
Morino Patrizia,
Bahro Marcel,
Cuénod Michel,
Streit Peter
Publication year - 1991
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1991.tb00824.x
Subject(s) - tectum , retinal , glutamate receptor , retina , biology , optic nerve , anatomy , midbrain , neuroscience , nucleus , lesion , biophysics , central nervous system , pathology , biochemistry , receptor , medicine
The pattern of glutamate‐like immunoreactivity was investigated in the pigeon optic tectum. The most impressive aspect of the labelling pattern was an accumulation of immunoreactive terminal‐like elements restricted to those superficial tectal layers that correspond to the termination zone of the retinal afferents. These immunoreactive puncta occurred frequently in small clusters. At the level of electron microscopy, many of the labelled nerve endings showed the characteristics of retinal terminals. Moreover, following unilateral retinal ablation a drastic loss of immunoreactive terminal‐like puncta was observed in the retinorecipient layers of the tectum contralateral to the lesion. The remaining glutamate‐immunoreactive terminal‐like elements had the light and electron microscopic features typical of the afferents from the nucleus isthmi, pars parvocellularis (lpc). The relation between the latter result and the transmitter specificity of the afferents from this subtectal nucleus is unclear at present. On the other hand, the light and electron microscopic labelling patterns and the effect of retinal ablation suggest that afferents from retina and from lpc are the only major sources for glutamate‐immunoreactive terminals in the pigeon optic tectum. Furthermore, the results are well in line with previous data indicating glutamate as neurotransmitter at least in part of the retinal afferents to the pigeon optic tectum.