Premium
Sensory Excitatory Postsynaptic Potentials Mediated by NMDA and non‐NMDA Receptors in the Thalamus in vivo
Author(s) -
Salt T. E.,
Eaton S. A.
Publication year - 1991
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.1991.tb00092.x
Subject(s) - excitatory postsynaptic potential , nmda receptor , long term depression , neuroscience , postsynaptic potential , glutamate receptor , receptor , stimulation , inhibitory postsynaptic potential , chemistry , biology , ampa receptor , biochemistry
Excitatory amino acid neurotransmitters, such as l ‐glutamate, act at several receptors in the brain, which are sometimes referred to as N ‐methyl‐ d ‐aspartate (NMDA) and non‐NMDA receptors. Extensive in vitro work indicates that both NMDA receptors and non‐NMDA receptors contribute to excitatory postsynaptic potentials (epsps). The contribution of NMDA receptors to epsps in vivo under physiological conditions is, however, almost unknown. The receptors that mediate the epsps evoked in thalamic relay cells by natural stimulation of sensory afferents have been investigated in anaesthetized rats, and we report the first pharmacological characterization of an excitatory amino acid receptor‐mediated epsp in vivo involving both non‐NMDA receptors and, in particular, NMDA receptors.