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Endometrial cancer in a 14‐year‐old girl with Cowden syndrome: A case report
Author(s) -
Baker William David,
Soisson Andrew Patrick,
Dodson Mark Kane
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.02052.x
Subject(s) - medicine , cowden syndrome , pten , endometrial cancer , endometrial polyp , breast cancer , cancer , lynch syndrome , disease , oncology , thyroid cancer , gynecology , dermatology , colorectal cancer , endometrium , apoptosis , biochemistry , chemistry , dna mismatch repair , pi3k/akt/mtor pathway
The appearance of endometrial cancer in adolescence is uncommon and warrants investigation for an hereditary cancer syndrome. Cowden syndrome is an autosomal dominant cancer syndrome associated with a germline PTEN mutation and increased risk of breast, thyroid, endometrial and colon cancer. In this report we present a case of a 14‐year‐old nulligravid female diagnosed with grade 1 endometrial adenocarcinoma. She subsequently developed fibrocystic breast disease and colon polyps and was diagnosed with Cowden syndrome at age 20. We therefore recommend formal evaluation for Cowden syndrome to be considered when endometrial cancer is diagnosed in adolescence.