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Positive correlation between serum levels of adiponectin and homocysteine in pre‐eclampsia
Author(s) -
Khosrowbeygi Ali,
Ahmadvand Hassan
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.02015.x
Subject(s) - adiponectin , homocysteine , medicine , eclampsia , pregnancy , endocrinology , plasma homocysteine , biomarker , population , obesity , biochemistry , insulin resistance , chemistry , biology , environmental health , genetics
Aim The aims of the present study were to assess the correlation between homocysteine and adiponectin and the homocysteine‐to‐adiponectin ratio in pre‐eclampsia compared with normal pregnant women. Materials and Methods The study population consisted of 30 women with pre‐eclampsia and 30 normal pregnant women. Serum levels of total adiponectin and total homocysteine were assessed using commercially available enzyme‐linked immunosorbent assay methods. Data are presented as median. Results Serum levels of total adiponectin correlated directly with total homocysteine in both pre‐eclampsia (r = 0.48, P = 0.01) and normal pregnancy (r = 0.68, P = 0.001). The homocysteine‐to‐adiponectin ratio was increased significantly in pre‐eclampsia compared with normal pregnancy (0.90 vs 0.70, P = 0.03). Compared with normal pregnancy, women with severe pre‐eclampsia showed significant increase in total adiponectin (14.29 vs 10.24, P = 0.01), total homocysteine (13.80 vs 7.25, P = 0.000) and homocysteine‐to‐adiponectin ratio (0.92 vs 0.70, P = 0.02). Women with mild pre‐eclampsia had higher values of total adiponectin (16.19 vs 10.24, P = 0.000) and total homocysteine (13.11 vs 7.25, P = 0.000) compared with normal pregnancy. No significant differences were observed between mild and severe pre‐eclampsia. Conclusion The present study showed a positive association between adiponectin and homocysteine in pre‐eclampsia. The homocysteine‐to‐adiponectin ratio may be an informative biomarker for the disease diagnosis and therapeutic monitoring.