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Significance of maternal screening for toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus infection in cases of fetal growth restriction
Author(s) -
Yamamoto Ryo,
Ishii Keisuke,
Shimada Mayumi,
Hayashi Syusaku,
Hidaka Nobuhiro,
Nakayama Masahiro,
Mitsuda Nobuaki
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.02012.x
Subject(s) - medicine , cytomegalovirus , rubella , torch , toxoplasmosis , rubella virus , incidence (geometry) , herpes simplex virus , fetus , obstetrics , serology , amniotic fluid , pregnancy , immunology , virology , pediatrics , antibody , herpesviridae , virus , viral disease , vaccination , biology , measles , materials science , physics , genetics , welding , metallurgy , optics
Aim The objective of this study was to evaluate the significance of maternal toxoplasmosis, rubella, cytomegalovirus ( CMV ) and herpes simplex virus ( TORCH ) screening in cases of fetal growth restriction ( FGR ). Material and Methods The medical records of women carrying fetuses with FGR who underwent TORCH screening over a 10‐year period were retrospectively reviewed for maternal and congenital TORCH infection. Women carrying fetuses with FGR routinely underwent serologic TORCH tests and systematic ultrasound evaluation for congenital abnormalities. If a congenital CMV infection was suspected, amniotic fluid, placenta or neonatal urine was used for CMV DNA detection by polymerase chain reaction. Results In 319 patients, no cases of maternal or congenital infection with toxoplasma, rubella, or herpes simplex virus were found. Conversely, six cases (1.8%) were diagnosed with congenital CMV infection, two of which had no structural abnormalities other than FGR . Conclusions A complete maternal TORCH screening for cases of FGR appears to be unnecessary. Although a maternal CMV test can be considered, the incidence of congenital CMV infection was found to be low in FGR cases.