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Risk factors of early and late onset pre‐eclampsia
Author(s) -
Aksornphusitaphong Adisorn,
Phupong Vorapong
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.02010.x
Subject(s) - medicine , odds ratio , eclampsia , family history , body mass index , diabetes mellitus , confidence interval , pregnancy , risk factor , obstetrics , relative risk , pediatrics , endocrinology , genetics , biology
Aims The aim of this study was to identify the differences in risk factors between early and late onset pre‐eclampsia. Material and Methods A case–control study was carried out involving pregnancies with pre‐eclampsia (152 early onset and 297 late onset) and 449 controls at K ing C hulalongkorn M emorial H ospital, B angkok, T hailand between 1 J anuary 2005 and 31 D ecember 2010. The data were reviewed from antenatal and delivery records. Results Factors which were significantly associated with increased risk for both early and late onset pre‐eclampsia were family history of diabetes mellitus, high pre‐pregnancy body mass index ≥ 25 kg/m 2 and weight gain ≥ 0.5 kg per week. History of chronic hypertension (odds ratio 4.4; 95% confidence interval 2.1–9.3) was significantly associated with increased risk for only early onset pre‐eclampsia, while family history of chronic hypertension (odds ratio 18; 95% confidence interval 6–54) was significantly associated with increased risk for only late onset pre‐eclampsia. Conclusions The risk factors that differ between early and late onset of pre‐eclampsia were history of chronic hypertension and family history of chronic hypertension. Family history of diabetes mellitus, pre‐pregnancy body mass index ≥ 25 kg/m 2 and weight gain ≥ 0.5 kg per week were risk factors of both early and late onset pre‐eclampsia. These risk factors are of value to obstetricians in identifying patients at risk for pre‐eclampsia and in implementing primary prevention.