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Clear cell adenocarcinoma arising from umbilical endometriosis
Author(s) -
Obata Koshiro,
Ikoma Naoko,
Oomura Gen,
Inoue Yoshiki
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.01964.x
Subject(s) - umbilicus (mollusc) , medicine , endometriosis , clear cell adenocarcinoma , adenocarcinoma , malignant transformation , umbilical cord , clear cell , lesion , pathology , clear cell carcinoma , nodule (geology) , magnetic resonance imaging , carcinoma , radiology , gynecology , cancer , anatomy , paleontology , biology
Umbilical endometriosis is a very rare condition, and as far as we are aware, there have been no reported cases of its malignant transformation. Here, we report a case of clear cell adenocarcinoma arising from umbilical endometriosis in a 60‐year‐old woman who underwent hysterectomy for a uterine myoma at the age of 38, and who denied cyclic bleeding at the site of an umbilical cutaneous nodule correlating with menses until the age of 48. An umbilical tumor (3 cm diameter) was identified by magnetic resonance imaging and an abnormal accumulation was found only at the umbilical lesion by positron emission tomography examination. We observed endometriosis adjacent to the clear cell adenocarcinoma and transformation to carcinoma from endometriosis at the umbilical lesion histopathologically. Clear cell adenocarcinoma of the umbilicus was thought to have arisen from endometriosis; it expressed HER‐2 protein and showed strong mesothelial characteristics immunohistochemically.