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TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like‐1 gene may have a role in stress urinary incontinence physiopathology
Author(s) -
Ozbek Emin,
Polat Emre Can,
Ozcan Levent,
Otunctemur Alper,
Emrence Zeliha,
Ustek Duran
Publication year - 2013
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.01942.x
Subject(s) - pathophysiology , lysyl oxidase , medicine , single nucleotide polymorphism , exon , gene polymorphism , gastroenterology , urinary incontinence , genotype , urinary system , allele , gene , endocrinology , pathology , genetics , urology , biology , extracellular matrix
Aim: In experimental studies, lysyl oxidase like‐1 (LOX‐L1) (−/−) mice were shown to have similar pelvic floor dysfunction to female rats. LOX‐L1 levels in endopelvic fascia decrease as a result of increasing births in women with pelvic prolapse. For these reasons, we investigated the LOX‐L1 gene polymorphism, which has an important role in connective tissue and collagenous metabolism in stress urinary incontinence (SUI). Materials and Methods: A total of 87 women with SUI who underwent normal vaginal delivery and 87 controls were involved in the study. Single nucleotide gene polymorphisms in LOX‐L1's rs1048661, G > T, pArg141Leu, Exon‐1 SmaI; rs3825942, C > T, pGly153Asp, Hinf‐1 and rs2165241, C > T, İntron‐1 BsrI regions were searched. The results were statistically compared as alleles with 3 × 2 χ 2 ‐test. Results: A total of 32 (34%) GG, 20 (21%) GT, 42 (45%) TT, 32 (37%) GG, 43 (39%) GT, 21 (24%) TT polymorphisms in rs1048661; 30 (36%) CC, 16 (19%) CT, 37 (45%) TT, 41 (59%) CC, 15 (22%) CT, 13 (19%) TT polymorphisms in rs2165241; and 63 (72%) CC, 21 (24%) CT, 3 (4%) TT; 48 (6%) CC, 22 (30%) CT, 3 (4%) TT polymorphisms in rs3825942 were found in patients and the control group, respectively. In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant. Conclusions: The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX‐L1 gene may be responsible from SUI physiopathology.