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Association between self‐reported questionnaire data on fertility and results of hormone analyses in women after childhood cancer: A cross‐sectional study
Author(s) -
Jantke Andreas,
Rendtorff Rosa,
Dittrich Ralf,
Müller Andreas,
Pfitzer Constanze,
Hohmann Cynthia,
Keil Thomas,
BorgmannStaudt Anja
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.01861.x
Subject(s) - medicine , menstrual cycle , luteinizing hormone , gynecology , amenorrhea , hormone , fertility , cross sectional study , anti müllerian hormone , follicle stimulating hormone , obstetrics , population , pregnancy , environmental health , pathology , biology , genetics
Aim: The aim of this study was to compare self‐reported questionnaire‐based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence. Material and Methods: In a cross‐sectional study, questionnaires and hormone analyses (anti‐Müllerian hormone [AMH], follicle‐stimulating hormone, luteinizing hormone, estradiol, progesterone) were evaluated in 86 female former pediatric oncology patients in Berlin in 2009. Results: Eighty‐six women (median age 23 years, range 19–41) participated in the study with a median follow up of 14 years (range 2–30) after diagnosis. Among women with information on permanent and transient amenorrhea, 9% (5/55) of the women stated that they were permanently amenorrheic. Among women not taking oral contraceptives and giving information on the regularity of their menstrual cycle, 18% (4/22) had an irregular menstrual cycle and 82% (18/22) had a regular menstrual cycle. The median AMH values for women who were categorized as infertile by questionnaire‐based information were significantly lower than the AMH values of women who were categorized as fertile by questionnaire (0.05 vs 2.2 ng/mL, P = 0.004). Questionnaire‐based categories on the regularity of the menstrual cycle and categories based on AMH values showed a satisfying percentage agreement (66.7%) and were moderately correlated (r = 0.42, P = 0.002). Conclusion: Self‐reported questionnaire data used to detect fertility impairment has limited correspondence with objectively measured AMH values.