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Subfertility in women with familial Mediterranean fever
Author(s) -
Zayed Abdelhady,
Nabil Hanan,
State Omnia,
Badawy Ahmed
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.01857.x
Subject(s) - medicine , intracytoplasmic sperm injection , infertility , gynecology , ovulation induction , anovulation , in vitro fertilisation , familial mediterranean fever , obstetrics , insemination , population , polycystic ovary , pregnancy , ovulation , sperm , andrology , disease , hormone , insulin , insulin resistance , genetics , environmental health , biology
Abstract Aim: The aim of this study was to examine the causes and different modalities used for management of subfertile patients with familial Mediterranean fever (FMF). Material and Methods: The study comprised of 74 infertile women with FMF. All patients were diagnosed as having FMF. All patients underwent a full infertility work‐up. They were scheduled to expectant treatment, ovulation induction and timed intercourse, intrauterine insemination or intracytoplasmic sperm injection. Results: Anovulation was reported in 18 patients (24.32%). Anovulation was due to polycystic ovary syndrome in 12 (16.22%) cases and due to other causes in six patients (8.11%). Excessive clear peritoneal fluid was present in 56 (57.67%) and male‐factor infertility was present in 14 couples (18.91%). Ovulation induction and timed intercourse was adopted for a maximum of six cycles and intrauterine insemination for three cycles. In vitro fertilization/intracytoplasmic sperm injection was needed in six cases using standard long agonist protocol. Twenty‐six women became pregnant. Conclusion: The causes of infertility in patients with FMF are not different from those expected in the general population. Treatment of the problem should be causal, adopting the conventional lines of treatment up to in vitro fertilization/intracytoplasmic sperm injection when appropriate. Colchicine is the treatment of choice and it is important to use it in its proper doses to control the disease.