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Antioxidant supplementation in pregnant women with low antioxidant status
Author(s) -
Wibowo Noroyono,
Purwosunu Yuditiya,
Sekizawa Akihiko,
Farina Antonio,
Idriansyah Liana,
Fitriana Ika
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2012.01855.x
Subject(s) - medicine , antioxidant , superoxide dismutase , placebo , eclampsia , gestation , pregnancy , physiology , gastroenterology , obstetrics , endocrinology , oxidative stress , biochemistry , pathology , biology , alternative medicine , genetics
Aim: The aim of this study was to investigate the benefit of antioxidant supplementation in a cohort of women with low antioxidant status and determine the changes in cell‐free mRNA. Material and Methods: This study was a randomized, placebo‐controlled trial of 8–12 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum. The primary end‐point was the risk of pre‐eclampsia and the secondary end‐point was the changes of angiogenic and anti‐oxidant mRNA markers related to the outcome (ClinicalTrial.gov, number NCT01232205). Results: There were 110 women enrolled in the study, randomly assigned to the supplementation ( n = 52) and control group ( n = 58). The overall rate of pre‐eclampsia was 8.7% (nine subjects). There were significant differences ( P = 0.034) between the supplementation and control group in the incidence of pre‐eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide‐dismutase, heme oxygenase‐1, vascular endothelial growth factor receptor‐1, endoglin and placental growth factor after supplementation. Conclusion: Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre‐eclampsia.