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Advanced extragonadal yolk sac tumor serially followed up with 18 F‐fluorodexyglucose‐positoron emission tomography and computerized tomography and serum alpha‐fetoprotein
Author(s) -
Baba Tsukasa,
Su Saori,
Umeoka Shigeaki,
Abiko Kaoru,
Nakamoto Yuji,
Mandai Masaki,
Matsumura Noriomi,
Konishi Ikuo
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01752.x
Subject(s) - medicine , yolk sac , positron emission tomography , abdomen , alpha fetoprotein , radiology , tomography , nuclear medicine , embryo , microbiology and biotechnology , hepatocellular carcinoma , biology
Although yolk sac tumors (YSTs) are the second most common malignant germ cell tumor of the ovary, those arising from the omentum or pelvic peritoneum are extremely rare and have no established treatment guidelines. We report a case of a primary YST disseminated throughout the abdomen and associated with a high serum alpha‐fetoprotein (AFP) elevation (441 611 ng/ml). Optimal cytoreduction was not achieved in order to preserve the patient's fertility and avoid adjacent organ injury. Residual tumor responded to adjuvant chemotherapy with a sharp decline in AFP levels, and confirmed remission was documented by serial 18 F‐fluorodexyglucose‐positoron emission tomography and computerized tomography (FDG‐PET/CT). In cases of advanced YST with unresectable residual disease, AFP levels combined with FDG‐PET/CT scans may be a helpful way to monitor treatment response and assist in treatment planning for a disease that primarily affects young women who may desire to preserve fertility.