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Effects of oxygenation and luminal flow on human placenta chorionic plate blood vessel function
Author(s) -
Wareing Mark
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01666.x
Subject(s) - medicine , vasodilation , oxygenation , electrical impedance myography , placenta , anatomy , hypoxia (environmental) , blood flow , contraction (grammar) , cardiology , fetus , biology , oxygen , pregnancy , chemistry , organic chemistry , genetics
Aim: The human fetoplacental vasculature has been suggested to be a low resistance/high flow system, but the mechanisms by which this state is achieved are unclear. Methods: This study assessed the effects of intraluminal flow and local oxygenation on isolated human placental chorionic plate arteries and veins at term using pressure myography. Results: Chorionic plate arteries and veins exhibit myogenic tone. A small but significant arterial vasodilatation was observed following exposure to hypoxia; chorionic plate veins contracted to a similar hypoxic stimulus. Under physiological conditions of pressure and oxygenation, increased luminal flow induced contraction in both chorionic plate arteries and veins. [Correction added after online publication 15th November 2011: ‘induced vasodilatation’ has been changed to ‘induced contraction’] Conclusions: Human fetoplacental vascular tone can be manipulated by local physical factors.