Premium
Annexin A2 in amniotic fluid: Correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery
Author(s) -
Namba Fumihiko,
Ina Shihomi,
Kitajima Hiroyuki,
Yoshio Hiroyuki,
Mimura Kazuya,
Saito Shigeru,
Yanagihara Itaru
Publication year - 2012
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01651.x
Subject(s) - amniotic fluid , chorioamnionitis , medicine , amnion , premature rupture of membranes , obstetrics , gestation , gestational age , andrology , fetus , pregnancy , biology , genetics
Aim: The aim of this study was to determine whether amniotic fluid levels of annexin A2, a phospholipid‐binding protein that is abundant in amnion and regulates fibrin homeostasis, are associated with histological chorioamnionitis, preterm premature rupture of the membranes, and subsequent preterm delivery. Materials and Methods: Amniotic fluid was obtained from 55 pregnant women with preterm labor and/or preterm premature rupture of the membranes before 32 weeks of gestation, and amniotic fluid levels of annexin A2 were measured with a sandwich enzyme‐linked immunosorbent assay. Results: Amniotic fluid levels of annexin A2 in patients with histological chorioamnionitis was higher than that in the remainder ( P = 0.053), whereas amniotic fluid levels of annexin A2 in patients with preterm premature rupture of the membranes was significantly higher than that in the remainder ( P = 0.002). Amniotic levels of annexin A2 was a fair test (area under receiver–operator characteristic curve = 0.679), and amniotic fluid levels of annexin A2 > 878.2 ng/mL had a sensitivity of 68.8%, a specificity of 65.2%, a positive predictive value of 73.3%, and a negative predictive value of 60.0% for predicting delivery within 2 weeks after amniotic fluid sampling. Furthermore, the combined use of amniotic fluid cut‐off levels of 878.2 ng/mL for annexin A2 and 13.3 ng/mL for interleukin‐8 improved the specificity (91.3%) and the positive predictive value (89.5%). Conclusions: We identified amniotic fluid levels of annexin A2, especially in combination with amniotic fluid levels of interleukin‐8, as a novel predictive marker for preterm delivery.