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Acquisition of anti‐Diego b antibodies possibly resulting from feto‐maternal hemorrhage during pregnancy
Author(s) -
Oishi Yuriko,
Watanabe Noriyoshi,
Ozawa Nobuaki,
Sago Haruhiko
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01599.x
Subject(s) - medicine , antibody , pregnancy , gestation , hemolysis , obstetrics , fetus , rh blood group system , hemolytic disease of the newborn (abo) , blood transfusion , immunology , genetics , biology
Anti‐Diego b (Di b ) antibodies, rare antibodies against red blood cell antigens, can cause severe hemolysis. We report a patient who most likely acquired anti‐Di b antibodies during pregnancy. The patient was a 39‐year‐old Japanese woman who delivered by cesarean section at 38 weeks of gestation. She required a second operation to treat re‐bleeding of the surgical scar, but it was difficult to schedule this surgery because we could not obtain enough blood for transfusion due to the presence of anti‐Di b antibodies. These antibodies were likely acquired during pregnancy; she did not have irregular antibodies at 11 weeks of gestation. We speculate that she became sensitized to fetal blood due to feto‐maternal hemorrhage. The infant had no hemolytic conditions. Testing for the presence of irregular antibodies should be performed during late stages of pregnancy as well as early stages.