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Rare case of spina bifida in both twins with possible genetic basis
Author(s) -
Lembet Arda,
Uğurlu Evin Nil,
Toprak Taner,
Bastu Ercan
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01597.x
Subject(s) - spina bifida , medicine , neural tube , etiology , placental abruption , obstetrics , gestation , fetus , pregnancy , neural tube defect , encephalocele , pediatrics , anatomy , pathology , genetics , embryo , biology
Neural tube defects (NTD) are a group of congenital malformations of the brain and spine, the etiology of which is still debated. Although presumed to be the consequence of interactions between genetic and environmental factors, so far, it is not known which genes are involved in the pathogenesis of these malformations. NTD affecting both fetuses in a twin gestation is a rare event. In view of this rarity, we present a case of dichorionic diamniotic twin pregnancy with spina bifida in both fetuses concordantly. This gestation was preceeded by another dichorionic diamniotic twin pregnancy that was complicated by placental abruption.