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Are serum markers altered in first trimester screening in poor ovarian reserve patients?
Author(s) -
Parlakgumus Huriye A.,
Haydardedeoglu Bulent,
Simsek Erhan,
Bulgan Kilicdag Esra,
Bagis Tayfun
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2011.01578.x
Subject(s) - medicine , ovarian reserve , first trimester , mann–whitney u test , nuchal translucency , gynecology , human chorionic gonadotropin , intracytoplasmic sperm injection , andrology , pregnancy , obstetrics , gestation , hormone , in vitro fertilisation , infertility , biology , genetics
Aim: To investigate whether serum biochemical markers were altered during first trimester screenings in patients who have diminished ovarian reserve. Methods: One hundred and fifty‐one women who conceived after intracytoplasmic sperm injection were enrolled during the 11‐ to 14‐week scan between June 2006 and July 2008. The normoresponders (Group 1: 125 patients) had >6 oocytes and the poor responders (Group 2: 26 patients) had ≤6 oocytes in oocyte retrieval. The means of the multiples of the median (MoM) of pregnancy‐associated plasma protein A (PAPP‐A), free β‐human chorionic gonadotropin (β‐hCG) and nuchal translucency of the poor responder and normoresponder groups were compared and a potential relationship between serum markers and poor ovarian reserve was investigated. Data were analyzed with the Student's t ‐test, χ 2 ‐test and Mann–Whitney two sample test (unpaired, nonparametric). P < 0.05 was considered significant. Results: The means of the MoMs of the poor responders and normoresponders were 1.16 ± 0.45 and 1.04 ± 0.32 ( P = 0.111) for nuchal translucency, 0.92 ± 0.48 and 0.89 ± 0.61 ( P = 0.399) for PAPP‐A, and 1.08 ± 0.40 and 1.21 ± 0.95 ( P = 0.831) for β‐hCG, respectively. Conclusion: There was no statistically significant difference between the groups in serum biochemical markers, nuchal translucency means and screen positive rates during the first trimester screening.