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Fetal nuchal translucency thickness in different cut‐off points for aneuploidy screening in the south of Vietnam
Author(s) -
Tomai XuanHong,
Schaaps JeanPierre,
Foidart JeanMichel
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01521.x
Subject(s) - aneuploidy , trisomy , medicine , nuchal translucency , obstetrics , nuchal translucency measurement , fetus , gynecology , pregnancy , prenatal diagnosis , chromosome , biology , genetics , gene
Aims: The purpose of this study was to define the most suitable cut‐off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. Material & Methods: Two thousand and five hundred cases of singleton pregnancies were followed prospectively from the first trimester to the delivery. The rate of aneuploidy was calculated by seeking a relationship to increased fetal nuchal translucency thickness then calculating the sensitivity and specificity of different cut‐off points in thickness measurement to find the most suitable point for screening. Results: The prevalence of fetal abnormality was 1.5% (95% CI 1.1–2.1), and 1.2% (95% CI 0.8–1.7) of aneuploidy cases found and the commonest was trisomy 21. A cut‐off point at 2.4 mm showed the highest level of sensitivity and specificity for the detection of aneuploidy (65.5 and 95.7%) and trisomy 21 (75.0 and 95.1%), with a false‐positive rate of 4.3 and 4.9%, respectively. Conclusion: Using a cut‐off point of nuchal translucency at 2.4 mm has potential for aneuploidy and trisomy 21 screening in the south of Vietnam.