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Fourteen‐year‐old girl with recurrent luteal‐phase‐dependent episodes of high fever
Author(s) -
Yamasaki Hideki,
Oki Toshimichi,
Iwamoto Ichiro,
Douchi Tsutomu
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01495.x
Subject(s) - medicine , luteal phase , agonist , menstrual cycle , hormone , endocrinology , gonadotropin releasing hormone agonist , follicular phase , gonadotropin releasing hormone , luteinizing hormone , receptor
Recurrent episodes of high fever during the luteal phase are exceedingly rare. A 14‐year‐old girl with a 1‐year history of recurrent febrile episodes associated with the menstrual cycle was referred to our department. Febrile episode (39–41°C) occurred for 10 to 12 days concomitantly with the luteal phase of each ovulatory cycle. To suppress the ovulatory cycle, gonadotropin releasing hormone agonist was administered for 5 months, and then febrile attack disappeared (34.5–36.2°C). Before and during gonadotropin releasing hormone agonist therapy, serum levels of inflammatory cytokines (interleukin [IL]‐1β, IL‐2, IL‐6, IL‐8, IL‐10, and tumor necrosis factor‐α) were unchanged and all of these were within the normal ranges. In our case, luteal‐phase‐dependent febrile episodes may not be attributable to the intervention of inflammatory cytokines as major fever mediators.