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Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction
Author(s) -
Wu WenYih,
Hsiao ShengMou,
Chang TingChen,
Lin HoHsiung
Publication year - 2011
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01370.x
Subject(s) - tolterodine , medicine , urology , overactive bladder , urine , alternative medicine , pathology
Abstract Aim: To investigate changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome, especially in patients with voiding dysfunction. Methods: Between January and December 2006, 44 patients were enrolled for six months of treatment with tolterodine. Pre‐treatment and post‐treatment urodynamic studies were scheduled for the enrolled patients. Results: Among the remaining 33 patients (11 dropped out), bladder capacity ( P < 0.001) and post‐void residual urine ( P = 0.009) increased, and functional urethral length ( P = 0.049) and pad weight test ( P = 0.03) decreased after treatment. Besides this, detrusor pressure at maximal urine flow, functional urethral length, maximal urethral pressure and maximal urethral closure pressure were less affected by tolterodine in patients with voiding dysfunction, compared to those without voiding dysfunction. Conclusions: Tolterodine treatment increased bladder capacity and decreased urine leakage; however, some urodynamic parameters in patients with voiding dysfunction were less affected by tolterodine treatment.