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Correlations between the detection of stress‐associated hormone/oxidative stress markers in umbilical cord blood and the physical condition of the mother and neonate
Author(s) -
Chiba Takako,
Omori Atsuko,
Takahashi Kenji,
Tanaka Kanako,
Kudo Kaori,
Manabe Mami,
Mariya Yasushi,
Kashiwakura Ikuo
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01292.x
Subject(s) - medicine , oxidative stress , hormone , adrenocorticotropic hormone , umbilical cord , endocrinology , apgar score , cord blood , pregnancy , body mass index , hemoglobin , birth weight , physiology , biology , immunology , genetics
Aim: The objective of this study was to assess the correlations between the detection of stress‐associated hormone/oxidative stress markers in umbilical cord blood (CB) and the physical condition of the mother and neonate. Methods: CB units collected from normal vaginal deliveries were analyzed for various biochemical markers, some stress‐associated hormones, such as progesterone, cortisol, adrenocorticotropic hormone (ACTH), corticotrophin releasing factor (CRF) and oxidative stress marker 8‐hydroxy‐deoxyguanosine (8‐OHdG), respectively. Results: The progesterone concentration closely correlated with Apgar score, hemoglobin, maternal smoking and insulin concentration, respectively. In particular, its concentration in the non‐smoker group and Apgar score 10 points group was significantly lower in comparison to the smoker group and Apgar score 8 points group, respectively. Cortisol concentration correlated significantly with the number of parities, pre‐pregnancy body mass index (BMI), and increase of neonatal weight and height per day, respectively. In particular, its concentration in deliveries of males and first babies was significantly higher in comparison to female deliveries and second babies, respectively. In addition, a significant correlation was observed between the duration between spontaneous/artificial membrane rupture time and delivery time and the ACTH concentration. However, no significant relationship was observed between maternal/neonatal factors and CRF concentration and 8‐OHdG concentration, respectively. A significant negative correlation was observed between cortisol and 8‐OHdG concentration. Conclusion: CB stress‐associated hormone/oxidative stress markers strongly reflect maternal and neonatal condition at the time of delivery.