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Factors related to recurrence in non‐obese women with endometrial endometrioid adenocarcinoma
Author(s) -
Panggid Kannika,
Cheewakriangkrai Chalong,
Khunamornpong Surapan,
Siriaunkgul Sumalee
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01289.x
Subject(s) - medicine , stage (stratigraphy) , body mass index , endometrial cancer , adenocarcinoma , gastroenterology , lymph node , oncology , gynecology , cancer , paleontology , biology
Aim: To evaluate the clinicopathological factors associated with recurrence of disease in non‐obese women with endometrial endometrioid adenocarcinoma. Methods: Medical records of the 138 patients who had newly diagnosed endometrial endometrioid adenocarcinoma with body mass index (BMI) <25 and underwent a complete staging surgery between 1999 and 2007 were reviewed. Results: The median age was 55 years (30–75 years). The median BMI was 21.3 (14.0–25.0). The International Federation of Gynecology and Obstetrics (FIGO) (1988) stages of the patients were as follows: 11 (8.0%) Ia, 30 (21.7%) Ib, 23 (16.7%) Ic, 5 (3.6%) IIa, 13 (9.4%) IIb, 12 (8.7%) IIIa, 2 (1.4%) IIIb, 38 (27.5%) IIIc, 4 (2.9%) IVb. Lymphovascular space invasion (LVSI) and lymph node metastasis was present in 73 (53%) and 38 (27.5%) patients, respectively. LVSI was significantly correlated with lymph node metastasis ( P < 0.0001), advanced FIGO stage ( P < 0.0001), poor histological grade ( P = 0.006), and deep uterine invasion ( P < 0.0001). The presence of LVSI, poor histological grade, and advanced stage were found significantly in patients who had disease recurrences ( P = 0.026, P < 0.001, and P = 0.015, respectively). Patients with LVSI, when stratified by FIGO stage, had a significant lower 5‐year overall survival rate (58.8% versus 76.3%, log–rank test, P = 0.04). Conclusion: LVSI, poor histological grade, and advanced stage were associated with disease recurrence in non‐obese women with endometrial endometrioid adenocarcinoma. Non‐obese patients with LVSI‐positive tumors tend to have a poorer survival rate than obese patients with LVSI‐positive tumors.