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Influence of previous abortions and new paternity on the risk of hypertension in nulliparous parturients in Ibadan: A cohort study
Author(s) -
Olayemi Oladapo,
Strobino Donna,
Adedapo Kayode,
Aimakhu Christopher,
Odukogbe Akintunde,
Salako Babatunde
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01268.x
Subject(s) - medicine , obstetrics , pregnancy , odds ratio , exact test , logistic regression , cohort , cohort study , prospective cohort study , multivariate analysis , gynecology , statistical significance , abortion , genetics , biology
Aim: This study aims to determine the influence of previous abortions and new paternity on the risk of hypertension in a cohort of nulliparous women. Methods: A prospective cohort study was conducted with development of hypertension in pregnancy as outcome variable. Explanatory variables were previous abortions and paternity. Univariate analysis was by t ‐test, χ 2 test and Fisher's exact test where applicable. Logistic regression was utilized for multivariate analysis. Stata was utilized for all the analyses. The level of statistical significance was set as P < 0.05. Results: Same paternity abortions reduced the risk of hypertension (OR 0.48, 95% CI 0.31–0.73). Previous abortions did not reduce the odds of hypertension in pregnancy (OR 1.25, 95% CI 0.83–1.88). Rural dwelling reduced the odds of developing hypertension in pregnancy (OR 0.54, 95% CI 0.42–0.70). Conclusion: The result of this study supports the immunological theory of the etiology of hypertension in pregnancy.