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Primary strumal carcinoid tumor of the ovary with multiple bone and breast metastases
Author(s) -
Kurabayashi Takumi,
Minamikawa Takahiro,
Nishijima Shota,
Tsuneki Ikunosuke,
Tamura Masaki,
Yanase Toru,
Hashidate Hideki,
Shibuya Hiroyuki,
Motoyama Teiichi
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01231.x
Subject(s) - medicine , chromogranin a , pathology , ovary , immunohistochemistry , synaptophysin , malignancy , carcinoid tumors
Although primary carcinoid tumor of the ovary is an extremely rare neoplasm, survival is excellent if the disease is confined to one ovary. Herein, we present a case of primary strumal carcinoid tumor of the ovary, stage IA, borderline malignancy, in a 34‐year‐old woman. Histological findings of the right ovary indicated higher atypical nuclei, higher mitotic rate and focal necrosis of tumorous cells in some areas, findings that are compatible with atypical carcinoid of the lung. Immunohistochemical staining was positive for synaptophysin, neuron‐specific enolase, chromogranin A, Ki‐67, topoisomerase IIα, peptide YY, and thyroglobulin. Three and a half years postoperatively, multiple bone and breast metastases were found and anticancer chemotherapy was ineffective. The results in the present case indicate that an ovarian carcinoid tumor found to be ‘atypical carcinoid’ according to pulmonary carcinoid criteria or immunohistochemical staining (i.e. highly positive for topoisomerase IIα and Ki‐67) may have a poor prognosis.