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Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype
Author(s) -
Yilmaz Bulent,
Gungor Tayfun,
Bayramoglu Hatice,
Soysal Sunullah,
Mollamahmutoglu Leyla
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01225.x
Subject(s) - gonadoblastoma , dysgerminoma , medicine , gynecology , ovary , karyotype , biology , biochemistry , chromosome , gene
Gonadoblastoma is a rare gonadal tumor with tumor cells arranged in nests surrounded by ovarian stroma containing Leydig or lutein‐type cells. In 50% of the cases, there is an overgrowth of germ cells with progression to dysgerminoma. A case of gonadoblastoma with coexisting dysgerminoma developing in both ovaries of a 20‐year‐old girl who had increased abdominal girth is presented here. A pelvic mass measuring 20 × 14 cm was detected by pelvic ultrasonography. Bilateral salphingo‐oophorectomy was performed. The histopathological report revealed bilateral gonadoblastoma with coexisting dysgerminoma. After surgery the patient received radiation and chemotherapy (BEP: bleomycin, etoposide, cisplatin) and was started on hormone replacement therapy. Five years and eight months after treatment, the patient is well and free of recurrence.