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Are heterochromatin polymorphisms associated with recurrent miscarriage?
Author(s) -
Caglayan Ahmet Okay,
Ozyazgan Isılay,
Demiryilmaz Fatma,
Ozgun Mahmut Tuncay
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01207.x
Subject(s) - recurrent miscarriage , medicine , miscarriage , etiology , chromosomal abnormality , karyotype , obstetrics , incidence (geometry) , gynecology , abnormality , chromosome abnormality , population , chromosome , pregnancy , genetics , biology , gene , physics , environmental health , optics , psychiatry
Aim: Recurrent miscarriage is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of chromosomal abnormalities and the frequency of a particular type of aberration in couples of Turkish origin with recurrent miscarriages compared with patients without miscarriages. Methods: A total of 336 patients with recurrent miscarriages and 427 patients without miscarriages were analyzed. Results: In the recurrent miscarriage group, a structural chromosomal abnormality was found in four patients (1%). Twelve patients had mosaic karyotype (3%) and the total rate of chromosomal abnormalities was 4% in this group. The karyotypes were composed of polymorphisms in 8% of patients with recurrent miscarriages compared with 4% in the control group ( P < 0.05). Conclusion: The overall high incidence of chromosome polymorphisms in patients with recurrent miscarriages compared to the normal population needs to be confirmed with additional investigations including larger populations in order to delineate the role of ‘harmless’ chromosomal aberrations in the etiology of recurrent spontaneous abortions.