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Transition of cytomegalovirus seropositivity in Japanese puerperal women
Author(s) -
Inde Yusuke,
Yamaguchi Satoru,
Kamoi Seiryu,
Takeshita Toshiyuki
Publication year - 2010
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2010.01176.x
Subject(s) - seroprevalence , medicine , seroconversion , serology , antibody , cytomegalovirus , obstetrics , immunology , human immunodeficiency virus (hiv) , viral disease , herpesviridae
Aim: To investigate the latest serological tendency of cytomegalovirus (CMV) in Japanese puerperal women and to estimate the sequential influence on child‐bearing women in Japan. Methods: We studied 3966 puerperal women registered at a cord blood bank. Serum samples were obtained from umbilical cords at delivery and on the third day after delivery. CMV immunoglobulin G (IgG) and CMV immunoglobulin M (IgM) antibodies were determined using enzyme immunoassay kits. Scatter diagrams between seroprevalences and perinatal details were generated, and Pearson product‐moment correlation coefficients ( r ) and coefficients of determination ( R 2 ) were calculated. Results: The overall CMV seroprevalence was 68.4% for the IgG antibody and 3.9% for the IgM antibody. IgM seroconversion had occurred separately in 0.28% of the cases without IgG seroconversion. Including outliers on scatter plots, linear decreasing trends were observed for IgG seropositivity with measurement year ( r = −0.72, P < 0.05, R 2 = 51.8%) and maternal birth year ( r = −0.43, P < 0.05, R 2 = 18.2%). There was a linear increasing tendency for IgG seroprevalence with maternal age ( r = 0.46, P < 0.05, R 2 = 21.4%). Without the outlier, a linear decreasing tendency was found for IgM seropositivity ( r = −0.85, P < 0.01, R 2 = 71.6%). Conclusion: CMV seropositivity decreased with maternal youth in Japanese puerperal women. A possible contradiction was identified: decreasing tendencies in the seroprevalence of both IgG and IgM might coexist. We assume that actual CMV infections spread in a transient epidemic manner in which it may not be possible to observe a linear tendency and/or that the actual risk of maternal CMV infection might be decreasing.