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Perinatal outcome of recurrent pre‐eclampsia versus pre‐eclampsia in nulliparas
Author(s) -
Chen YiYung,
Wu MaoLin,
Kao MeiHua,
Su TsungHsien,
Chen ChiePein
Publication year - 2009
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2009.01057.x
Subject(s) - medicine , eclampsia , obstetrics , proteinuria , blood pressure , pregnancy , gestational age , preeclampsia , small for gestational age , gynecology , genetics , biology , kidney
Aim: The aim of the study was to compare the perinatal outcome of recurrent pre‐eclampsia in multiparas with that of pre‐eclampsia in nulliparas. Methods: This retrospective study was performed by collecting maternal and perinatal data from records of women with pre‐eclampsia who delivered at Mackay Memorial Hospital over a 10‐year period. Fifty women with recurrent pre‐eclampsia were compared with 207 women who developed pre‐eclampsia as nulliparas. In the 50 multiparas, the outcome of recurrent pre‐eclampsia was also compared with that of their earlier episodes of pre‐eclampsia. Maternal and fetal variables compared included maternal blood pressure, serum biochemistry, rate of preterm delivery, rate of abruptio placentae and neonatal outcome. Results: Compared with nulliparous women with pre‐eclampsia ( n = 50), women with recurrent pre‐eclampsia ( n = 207) had a smaller increase in mean maternal blood pressure (27.0 ± 18.9 mmHg vs 34.3 ± 19.3 mmHg, P = 0.021), less dipstick proteinuria (≥++; 36.0 vs 58.5%, P = 0.004), and bore children with a heavier mean birthweight (2909.1 ± 895.5 g vs 2551.1 ± 933.0 g, P = 0.017). No significant statistical difference was found in the gestational age of delivery, maternal serum biochemical levels and rate of abruptio placentae or preterm delivery. Within the multiparous group ( n = 50), recurrent disease was associated with a lower mean maternal blood pressure and dipstick proteinuria and with higher birthweight than in their previous pre‐eclamptic pregnancies. Conclusion: Recurrent pre‐eclampsia appears to be less severe and to have a better perinatal outcome than pre‐eclampsia in nulliparas.