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Luteoma‐induced fetal virilization
Author(s) -
Ugaki Hiromi,
Enomoto Takayuki,
Tokugawa Yoshihiro,
Kimura Tadashi
Publication year - 2009
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2009.01046.x
Subject(s) - virilization , medicine , asymptomatic , pregnancy , testosterone (patch) , fetus , obstetrics , ovary , lesion , gynecology , hormone , pathology , androgen , endocrinology , biology , genetics
A pregnancy luteoma represents an unusual response of ovarian stromal cells to the altered hormonal levels of pregnancy. It is a distinctive non‐neoplastic lesion characterized by solid proliferations of luteinized cells resulting in a tumor‐like ovarian enlargement. Most patients are asymptomatic; the ovarian enlargement is usually discovered incidentally at cesarean section or during postpartum tubal ligation. We report a typical case that we found at cesarean section to be associated with a virilized infant who manifested clitoromegaly and labial fusion. We detected an increased level of testosterone in the maternal patient. We concluded that the ovarian luteoma induced the fetal virilization.