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Midtrimester termination of pregnancy using gemeprost in combination with laminaria in women who have previously undergone cesarean section
Author(s) -
ObataYasuoka Mana,
Hamada Hiromi,
Watanabe Hideki,
Shimura Rena,
Toyoda Maki,
Yagi Hiroya,
Takeshima Kinuko,
Abe Kanako,
Nakamura Yoshiko,
Ogura Tsuyoshi,
Fujiki Yutaka,
Yoshikawa Hiroyuki
Publication year - 2009
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2009.01044.x
Subject(s) - medicine , laminaria , pregnancy , obstetrics , cervical dilation , uterine rupture , abortion , odds ratio , gestation , gynecology , uterus , ecology , genetics , algae , biology
Aim: We aimed to assess the efficacy and safety of midtrimester termination of pregnancy using gemeprost in combination with laminaria in women who had previously undergone cesarean section and in women who had not. Methods: Between January 1999 and December 2006, we carried out a retrospective study of termination of pregnancy at 12–21 weeks of gestation at the University of Tsukuba Hospital. Termination of pregnancy was carried out by three‐step uterine cervical dilation using laminaria followed by vaginal administration of 1 mg gemeprost every 3 h for up to four doses over 24 h. Results: A total of 173 women underwent midtrimester termination of pregnancy. The women were categorized into two groups: those who had previously undergone cesarean section ( n = 26) (previous cesarean section group) and those who had not ( n = 147) (control group). Seven women had undergone cesarean section at least twice. The gemeprost dose administered was 2.8 ± 1.4 mg for the previous cesarean section group and 2.4 ± 1.6 mg for the control group (difference in doses not significant). Although abnormal vaginal bleeding (>500 mL) was more likely to occur in the previous cesarean section group than in the control group (odds ratio, 2.61; 95% confidence interval, 0.63–10.82), none of the woman required blood transfusion. Uterine rupture and failed abortion were not observed. Conclusion: The efficacy and safety of our laminaria‐gemeprost protocol for termination of pregnancy during the midtrimester are similar for women who have previously undergone cesarean section and those who have not.