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Neonatal C‐reactive protein value in prediction of Outcome of Preterm Premature Rupture of Membranes: Comparison of Singleton and Twin Pregnancies
Author(s) -
Taghavi Simin,
Melli Manijeh Sayyah,
Barband Alireza,
Atashkhoui Simin,
Sheikhvatan Mehrdad
Publication year - 2009
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2009.01013.x
Subject(s) - medicine , neonatal intensive care unit , odds ratio , premature rupture of membranes , gestational age , obstetrics , singleton , rupture of membranes , twin pregnancy , white blood cell , mechanical ventilation , c reactive protein , pediatrics , pregnancy , gestation , inflammation , biology , genetics
Aim: The clinical importance of preterm premature rupture of the membranes (PPROM) is its relationship to maternal and neonatal mortality and morbidity, especially in twin pregnancies. The aim of this study was to determine and compare the role of inflammatory factors as predictors of the PPROM outcome between singleton and twin pregnancies. Methods: The medical records of 22 twins delivered between 28 and 34 weeks and complicated by PPROM were reviewed at the Al‐Zahra Hospital in Tabriz, Iran. Also among singletons, 55 cases of matched gestational age were randomly selected as a control group. Three laboratory indices of neonatal white blood cell (WBC) count and C‐reactive protein (CRP) in the two groups were measured immediately after delivery and the effects of two factors on neonatal outcome were assessed. Results: In singletons, there was adverse relationship between the mean of WBC count and duration of latency ( P = 0.007). Also, a positive relationship between the means of ventilation time and WBC count in second twins was found ( P = 0.034). Positive CRP was the main predictor of neonatal intensive care unit admission in both singletons (odds ratio: 4.929, P = 0.042) and first twins (odds ratio: 9.000, P = 0.005). However, positive CRP did not influence the existence of metabolic acidosis or duration of latency in either of the two groups. Conclusion: Neonatal WBC count was a predictor for the duration of latency in singletons and for ventilation time in twins. Positive neonatal CRP was an important factor for the prediction of neonatal intensive care unit admission in both types of pregnancy; its role in twins is clearer than in singletons.