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Soluble tumor necrosis factor receptor‐I in preterm infants with chorioamnionitis
Author(s) -
Sato Miho,
Nishimaki Shigeru,
An Hiromi,
Shima Yoshio,
Naruto Takuya,
Sugai Toshiyuki,
Iwasaki Shiho,
Seki Kazuo,
Imagawa Tomoyuki,
Mori Masaaki,
Yokota Shumpei
Publication year - 2009
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2008.00949.x
Subject(s) - medicine , chorioamnionitis , cord blood , gestational age , stage (stratigraphy) , gastroenterology , tumor necrosis factor alpha , obstetrics , anesthesia , pregnancy , paleontology , genetics , biology
Aim: The aim of our study was (i) to determine whether chorioamnionitis (CAM) is associated with an elevated soluble tumor necrosis factor receptor I (sTNFR‐I) level and (ii) to examine the time course of the concentration of sTNFR‐I in preterm infants after birth. Methods: We measured sTNFR‐I levels in the cord blood of 112 preterm infants (gestational age ≤34 weeks), and those in peripheral blood of 30 preterm infants on days 7, 14, 21 and 28. Results: The median value for the sTNFR‐I was significantly elevated in 33 infants with CAM at stage 3 (4618 pg/mL) compared with the 52 infants without CAM (2866 pg/mL), or the 13 infants with CAM at stage 1 (3638 pg/mL) and the 14 infants at stage 2 (3242 pg/mL). The severity of CAM is an independent factor for the elevation of cord blood sTNFR‐I. The sTNFR‐I level on day 0 was significantly higher in eight infants with CAM at stage 3 than in the 22 infants without CAM or with CAM at stage 1 and 2; however there were no significant differences on days 7, 14, 21 and 28. The serum level of sTNFR‐I showed a significant gradual decline with time. Conclusions: We suggest that there is an association between elevated sTNFR‐I levels in cord blood and maternal CAM, and this elevation may reflect the fetal inflammation. However the elevation of sTNFR‐I could not persist postnatally for a long time.