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Depth of invasion for appendiceal metastasis of ovarıan cancers: Does it have any clinical significance?
Author(s) -
Ayhan Ali,
Gultekin Murat,
Sağlam Emine Arzu,
Dursun Polat,
Dogan Nasuh Utku,
Aksan Guldeniz,
Usubutun Alp,
Yuce Kunter
Publication year - 2008
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2008.00816.x
Subject(s) - medicine , clinical significance , metastasis , general surgery , pathology , oncology , cancer
Aim: Depth of appendiceal metastasis in patients with epithelial ovarian carcinoma (EOC) has not been previously analyzed for a possible relationship with clinico‐pathological variables. Methods: Sixty‐nine patients with EOC treated at Hacettepe University were retrospectively analyzed. All of the patients had appendiceal metastasis. Pathological slides were re‐reviewed by the same pathologist. Appendiceal metastases were defined as serosal (if tumoral spread involved only serosa of the appendix) or sero‐mucosal (if tumoral spread also involved either muscular or mucosal surfaces of the appendix). Univariate and multivariate analysis did not reveal a significant difference with respect to the prognostic variables between the groups. Results: Thirty‐nine patients had serosal appendiceal metastasis (56.5%), while the remaining 30 patients (43.5%) had appendiceal metastasis extending toward the muscular layer (seromucosal metastasis: 16 within muscularis mucosa, 14 within the mucosa of the appendix). The mean age at the time of diagnosis was 54.58 years (range, 26‐88 years), with no significant difference between the groups ( P = 0.9). Comparison of the survival rates between the two groups did not reveal a significant difference. Three‐year survival rates were 23.3% in the serosal metastasis and 27.9% in the seromucosal metastasis group ( P = 0.9). This figure was 25% for patients with only muscular metastasis and 41.6% for patients with appendiceal metastasis extending to the mucosal layer ( P = 0.2). Conclusion: This is the first report to analyze the metastatic pattern of EOC on the appendix with respect to depth of invasion which could not reveal a significant difference.