Premium
Adenocarcinoma arising from respiratory ciliated epithelium in benign cystic teratoma of the ovary: A case report with analyzes of the CT, MRI, and pathological findings
Author(s) -
Yahata Tetsuro,
Kawasaki Takashi,
Serikawa Takehiro,
Suzuki Mina,
Tanaka Kenichi
Publication year - 2008
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2008.00784.x
Subject(s) - medicine , adenocarcinoma , pathology , malignancy , malignant transformation , teratoma , ovary , respiratory epithelium , immunohistochemistry , clear cell adenocarcinoma , mature cystic teratoma , pathological , mature teratoma , magnetic resonance imaging , epithelium , radiology , cancer , clear cell
The malignant transformation of mature cystic teratoma is rare, thus occurring in only 1–2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. Adenocarcinoma occurs with less frequency. We herein present a patient with an ovarian mature cystic teratoma who demonstrated a malignant transformation to well‐differentiated adenocarcinoma. Malignant transformation was diagnosed preoperatively by contrast enhanced computed tomography (CT) and magnetic resonance imaging (MRI). Microscopically and immunohistochemically, the adenocarcinoma was considered to have arisen from the ciliated respiratory epithelium. After a 28‐month of follow‐up period, she remains free of the disease. This is the third reported case of adenocarcinoma arising in the respiratory epithelium of an ovarian mature cystic teratoma. Contrast enhanced CT and MRI are useful for making a preoperative diagnosis and an immunohistochemical study is helpful for defining its origin.