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Small cell carcinoma of the uterine cervix metastasizing to the bone marrow: A case report
Author(s) -
Ota Tsuyoshi,
Kitano Takamitsu,
Miyai Kentaro,
Ogishima Daiki,
Yoshida Manabu,
Miyake Kazunori,
Kinoshita Katsuyuki
Publication year - 2008
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2008.00731.x
Subject(s) - medicine , uterine cervix , cervix carcinoma , carcinoma , bone marrow , cervix , pathology , gynecology , oncology , cervical carcinoma , cancer , cervical cancer
We report a case of small cell carcinoma (SmCC) of the uterine cervix that metastasized to the bone marrow. A 60‐year‐old woman with stage IIB SmCC of the cervix was treated with three courses of neoadjuvant chemotherapy followed by radical hysterectomy. Because of the presence of a large residual tumor, the patient underwent postoperative adjuvant chemotherapy. Two months after the last course of chemotherapy, severe pancytopenia developed, and erythroblastic cells were found in the peripheral blood. The hematological disorder was shown to be secondary to bone marrow metastasis, and no other metastases were found. The patient died of the disease 8 months after the initial diagnosis. This case suggests that SmCC of the cervix can metastasize to bone marrow, that such metastasis can occur in isolation and lead to severe pancytopenia, influencing the clinical course of the disease.