Premium
Complete hydatidiform mole with coexisting dichorionic diamniotic twins following testicular sperm extraction and intracytoplasmic sperm injection
Author(s) -
Yamada Takahiro,
Matsuda Takao,
Kudo Masataka,
Yamada Takashi,
Moriwaki Masashi,
Nishi Shinya,
Ebina Yasuhiko,
Yamada Hideto,
Kato Hidenori,
Ito Tomoo,
Wake Norio,
Sakuragi Noriaki,
Minakami Hisanori
Publication year - 2008
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2007.00714.x
Subject(s) - intracytoplasmic sperm injection , testicular sperm extraction , human fertilization , sperm , andrology , in vitro fertilisation , oocyte , medicine , azoospermia , gynecology , pregnancy , biology , genetics , embryo , infertility , anatomy
We present the first report of complete hydatidiform mole (HM) with coexisting dichorionic diamniotic twins. This pregnancy was achieved after testicular sperm extraction and intracytoplasmic sperm injection (ICSI) for azoospermia in the woman's husband. Standard in vitro fertilization may cause multisperm fertilization and increase triploid partial HM and complete HM, which arise from dispermic fertilization. In contrast, ICSI can avoid multisperm fertilization. In our case, paternal isodisomy in the molar tissue was confirmed by microsatellite analysis suggesting that it resulted from duplication of a haploid paternal genome following monospermic fertilization of an inactivated oocyte or from monospermic fertilization of an inactivated oocyte with a diploid sperm. Although the patient was eager to continue the pregnancy, the size of the HM component increased rapidly and termination of the pregnancy was required for pre‐eclampsia‐like symptoms at 15 weeks of gestation. After the operation, chemotherapy was initiated for persistent trophoblastic disease.