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Association of microsomal epoxide hydrolase gene polymorphism and pre‐eclampsia in Turkish women
Author(s) -
Pinarbasi Ergun,
Percin Ferda E.,
Yilmaz Meral,
Akgun Egemen,
Cetin Meral,
Cetin Ali
Publication year - 2007
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2007.00473.x
Subject(s) - microsomal epoxide hydrolase , exon , epoxide hydrolase , genotype , eclampsia , medicine , preeclampsia , intron , polymorphism (computer science) , genetic association , gene , enzyme , endocrinology , genetics , biology , pregnancy , single nucleotide polymorphism , biochemistry , microsome
Aim: To assess the association between human epoxide hydrolase exon 3 and 4 polymorphisms and pre‐eclampsia by carrying out a case‐control study in Turkish women. Methods: DNA was extracted from peripheral blood leukocytes, and genotype distribution of exon 3 and exon 4 of epoxide hydrolase gene ( EPHX ) was carried out in 271 patients and 155 controls. Results: There was no statistically significant difference in the distribution of genotypes between pre‐eclampsia without HELLP and pre‐eclampsia plus HELLP cases and controls for the exon 3 and 4 polymorphism of EPHX . However, we found a significant association between the predicted enzyme activity level and pre‐eclampsia ( P = 0.018). The distribution of subjects with predicted high, intermediate and low microsomal epoxide hydrolase enzyme (EPHX) activity were 23.2, 38.8 and 38% in cases and 12, 47.3 and 40.7% in controls, respectively. Conclusion: Although we could not find any association between genetic variability in exon 3 and 4 of EPHX and pre‐eclampsia, genetic variability in these two exons jointly modifies the predicted enzyme activity and may be a risk factor for pre‐eclampsia.